Diabetes drug makes brain cells grow

The widely used diabetes drug metformin comes with a rather unexpected and alluring side effect: it encourages the growth of new neurons in the brain. The study reported in the July 6th issue of Cell Stem Cell, a Cell Press publication, also finds that those neural effects of the drug also make mice smarter. See Also: Health & Medicine Brain Tumor Stem Cells Nervous System Mind & Brain Brain Injury Intelligence Neuroscience Strange Science Reference Neural development Stem cell treatments Diabetes mellitus type 2 Embryonic stem cell The discovery is an important step toward therapies that aim to repair the brain not by introducing new stem cells but rather by spurring those that are already present into action, says the study's lead author Freda Miller of the University of Toronto-affiliated Hospital for Sick Children. The fact that it's a drug that is so widely used and so safe makes the news all that much better. Earlier work by Miller's team highlighted a pathway known as aPKC-CBP for its essential role in telling neural stem cells where and when to differentiate into mature neurons. As it happened, others had found before them that the same pathway is important for the metabolic effects of the drug metformin, but in liver cells. "We put two and two together," Miller says. If metformin activates the CBP pathway in the liver, they thought, maybe it could also do that in neural stem cells of the brain to encourage brain repair. The new evidence lends support to that promising idea in both mouse brains and human cells. Mice taking metformin not only showed an increase in the birth of new neurons, but they were also better able to learn the location of a hidden platform in a standard maze test of spatial learning. While it remains to be seen whether the very popular diabetes drug might already be serving as a brain booster for those who are now taking it, there are already some early hints that it may have cognitive benefits for people with Alzheimer's disease. It had been thought those improvements were the result of better diabetes control, Miller says, but it now appears that metformin may improve Alzheimer's symptoms by enhancing brain repair. Miller says they now hope to test whether metformin might help repair the brains of those who have suffered brain injury due to trauma or radiation therapies for cancer.

Spanish Tourism Industry Prepares for Difficult Summer

Spain's tourism industry is bracing itself for a painful slowdown in bookings this summer, driven by a steep decline in local tourism, according to the country's leading hotel association. Reservations by Spanish vacationers for the month of July are 30% lower than last year, amid persistently high unemployment and a protracted economic recession, said Juan Molas, president of the Spanish Confederation of Hotels and Tourist Accommodations. An influx of visitors from Russia and other countries in Eastern Europe has compensated somewhat for the decline in local tourism, but weak local demand is expected to weigh on an industry that accounts for about 11% of Spain's annual economic output. Hotel owners are concerned that the government may raise the industry's value-added tax to 18% from the current 8%, in a bid to reduce its yawning budget deficit, making Spain less attractive to foreign tourists compared with other less expensive destinations "If the VAT rises to 18%, it will be absolutely catastrophic for the sector," Mr. Molas said at an event Thursday in Madrid. Spain's government is working to secure €100 billion ($126 billion) in aid for its struggling banking sector from the European Union and plans to meet with EU officials next week to discuss new measures to improve its public finances. Prime Minister Mariano Rajoy has already implemented €45 billion in austerity measures, but weak tax revenue threatens to undermine his administration's goal of trimming its shortfall this year to 5.3% of gross domestic product from 8.9% last year. Sentiment in the hospitality industry is at its lowest level since 2009, according to an index developed by the hotel association and consulting firm PwC. Based on a survey of hotel firms, 57% of operators expect international tourism will hold steady this year, while 76% expect domestic tourism to decline. "The parts of the country that will suffer the most are those that cater to national tourists," Mr. Molas said.

Holidaymakers in Spain this summer are facing a surprise new airport tax imposed by the Spanish government

Holidaymakers in Spain this summer are facing a surprise new airport tax imposed by the Spanish government as it tries to balance its books. Some airlines are passing the new departure tax on to passengers, even if they booked their flights months ago. Some passengers have received emails telling them either to pay an extra charge of up to seven euros (£6) per person - or to cancel their flights. Other airlines are deciding whether to absorb the cost themselves. The budget airline Ryanair said Spain's 2012 budget, passed into law at the end of June, obliged airlines to pay increased taxes. Spain is implementing drastic measures to try to slash its budget deficit to 5.3% from 8.5% in 2011. It has been promised bailout funds of up to 100bn euros for its banks, but wants to avoid a full state bailout. Retrospective The European travel agents' association ECTAA said the amount of the extra levy varied depending on which airport people used. It said the average rise in the tax was 18.9%, but at some of the larger airports it would almost double. For instance, at Madrid-Barajas the tax would rise from 6.95 euros to 14.44, while at Barcelona's El Prat airport it would rise from 6.12 euros to 13.44. Ryanair said it would pass the cost on to passengers, even those who had already paid in full for their flights, because the tax applied "retrospectively to customers who booked flights before 2 July 2012 and are travelling from 1 July onwards". It said for bookings made on or after 2 July, the increased tax would have been included in the price. The Spanish low-cost airline Vueling is also passing on the cost. It sent emails to passengers giving them seven days to cancel their flight, or the extra payment would be debited automatically from the card they used to book. British Airways and Iberia told the BBC they had not yet decided whether to pass on the cost or absorb it. ECTAA said in a statement it was "dismayed" by the rise, which was imposed "without proper consultation of airport users nor appropriate implementation time". It said travel agents faced a "technical and financial nightmare to recover the extra charge".

Beware of missed call to check SIM cloning

Next time if you get a missed call starting with +92; #90 or #09, don't show the courtesy of calling back because chances are it would lead to your SIM card being cloned. The telecom service providers are now issuing alerts to subscribers —particularly about the series mentioned above as the moment one press the call button after dialing the above number, someone at the other end will get your phone and SIM card cloned. According to reports, more than one lakh subscribers have fallen prey to this new telecom terror attack as the frequency of such calls continues to grow. Intelligence agencies have reportedly confirmed to the service providers particularly in UP West telecom division that such a racket is not only under way but the menace is growing fast. "We are sure there must be some more similar combinations that the miscreants are using to clone the handsets and all the information stored in them," an intelligence officer told TOI. General Manager (GM) BSNL, RV Verma, said the department had already issued alerts to all the broadband subscribers and now alert SMSes were being issued to other subscribers as well. As per Rakshit Tandon, an IT expert who also teaches at the police academy (UP), the crooks can use other combination of numbers as well while making a call. "It is better not to respond to calls received from unusual calling numbers," says Tandon. "At the same time one should avoid storing specifics of their bank account, ATM/ Credit/Debit card numbers and passwords in their phone memory because if one falls a prey to such crooks then the moment your cell phone or sim are cloned, the data will be available to the crooks who can withdraw amount from your bank accounts as well," warns Punit Misra; an IT expert who also owns a consultancy in Lucknow. The menace that threatens to steal the subscriber's information stored in the phone or external memory (sim, memory & data cards) has a very scary side as well. Once cloned, the culprits can well use the cloned copy to make calls to any number they wish to. This exposes the subscribers to the threat of their connection being used for terror calls. Though it will be established during the course of investigations that the cellphone has been cloned and misused elsewhere, it is sure to land the subscriber under quite some pressure till the time the fact about his or her phone being cloned and misused is established, intelligence sources said. "It usually starts with a miss call from a number starting with + 92. The moment the subscriber calls back on the miss call, his or her cell phone is cloned. In case the subscribers takes the call before it is dropped as a miss call then the caller on the other end poses as a call center executive checking the connectivity and call flow of the particular service provider. The caller then asks the subscriber to press # 09 or # 90 call back on his number to establish that the connectivity to the subscriber was seamless," says a victim who reported the matter to the BSNL office at Moradabad last week. "The moment I redialed the caller number, my account balance lost a sum of money. Thereafter, in the three days that followed every time I got my cell phone recharged, the balance would be reduced to single digits within the next few minutes," she told the BSNL officials.

France brings in breathalyser law

New motoring laws have come into force in France making it compulsory for drivers to carry breathalyser kits in their vehicles. As of July 1, motorists and motorcyclists will face an on-the-spot fine unless they travel with two single-use devices as part of a government drive to reduce the number of drink-drive related deaths. The new regulations, which excludes mopeds, will be fully enforced and include foreigner drivers from November 1 following a four-month grace period. Anyone failing to produce a breathalyser after that date will receive an 11 euro fine. French police have warned they will be carrying out random checks on drivers crossing into France via ferries and through the Channel Tunnel to enforce the new rules. Retailers in the UK have reported a massive rise in breathalyser sales as British drivers travelling across the Channel ensure they do not fall foul of the new legislation. Car accessory retailer Halfords said it is selling one kit every minute of the day and has rushed extra stock into stores to cope with the unprecedented demand. Six out of 10 Britons travelling to France are not aware they have to carry two NF approved breathalysers at all times, according to the company. The French government hopes to save around 500 lives a year by introducing the new laws, which will encourage drivers who suspect they may be over the limit to test themselves with the kits. The French drink-driving limit is 50mg of alcohol in 100ml of blood - substantially less than the UK limit of 80mg.

Animal-human hybrid stickers invading Parisian streets

While marketing and mainstream communications campaigns have derived branding inspiration in the comic-like cartoon style of street art, and the values attached to its culture—freedom, community, transgression—the paradox still exists to see it framed and sold through traditional art channels.

We caught up with street artist Rafael Suriani at his recent show, "Collages Urbains", at Cabinet d'amateur gallery in Paris, where he told us more about street art and his relationship with the medium.

Suriani's mark features animals, surviving and thriving in the streets for its powerful and highly recognizable aesthetic. In his half-human-half-animal figures, the animal faces act as liberating masks, allowing the artist to express social criticism in an elegant way. The vibrant, seemingly playful creatures refrain from getting too serious and maintain a suggestive tone that avoids the obvious.

 

The stickers are the result of a double-binding process that first assembles man and animal, then adheres the resulting figure to the wall. In the past, Suriani has drawn from his Latin-American heritage, playing with shamanic mythology figures such as toucan or jaguar. In his recent series, on the other hand, he is more interested in urban domestic animals such as cats and dogs—according to the artist, the convention that they tend to resemble their owners offers a metaphoric way to talk about us people. Recently Suriani made a series of French "Bulldogs" as a special dedication on London walls, using this breed to cartoon and make fun of some French characteristics. Each dog expresses a different state of mind—humor, spirituality, criticism or beauty.

 

Suriani uses the rare technique of hand-painting every poster he sticks on the streets. Making each sticker is the result of a process involving selecting photos from the Internet, cutting them in Photoshop, then screening and painting before cutting the final product. Such repetition lies at the heart of street art practice, which is often based on plastering as many spots as possible, invasion-style.

When considering the ephemeral fate of the piece of work destined for degradation of the elements, police destruction or theft from passers-by, the time and effort for such little reward seems remarkable. Suriani explains, however, that the fleeting nature of his work is freeing and allows him to be audacious with both subject and technique. To him, because there is no pressure or constraint, that achievement is rarely a failure.

In the end, the piece of art is not the only sticker by itself, it is the sticker in its context, seen as a whole on the wall with the daylight shining on it, the motorbikes parked against it or the branch of a tree creeping across. Rarely is the work's time spent on the wall its only life, after all, with the rise of dedicated photographers immortalizing the scenes for the Internet.

Suriani claims his intention to step into the city's landscape by bringing much-needed beauty comes with a positive message. Rather than being aggressive or controversial, Suriani takes pleasure in having people on the street enjoy his figures. His work is bound to the city—physically, geographically and socially—compelling the public to refresh their view of their surroundings and drawing their eyes to the places that typically go unnoticed. As an architect, Suriani has found a way to unveil the city and change people's perception of the scenes they see everyday without truly seeing them. The choice of venue is very important, based on aesthetic consideration with attention to the context and surroundings like the location.

EURO 2012 POSTERS BY DAVID WATSON

Euro 2012 recently began and, for those of you who don’t know, it’s the European football championship. European football is what we Americans call soccer, and it has slowly gained steam over the years, although still not as popular as American football…  Whether you’re into the championship or not (or even sports in general), you’ll probably love these simple, modern posters David Watson ofTrebleseven designed for it.

 

Each poster represents a particular country that’s playing, and the colors of their flag are incorporated into one of the various circular designs. I love the typographic twist these posters have and how they don’t have blatant sports references in them.